Ly6/PLAURdomaincontaining3(LYPD-3),isaGPI-linkedprotein.ThestructuralofLYPD-3issimilaritytotheurokinase-typeplasminogenactivatorreceptor(uPAR)(1).LYPD-3isa65-100kDamoleculewithvariablecelltype-specificN-O-linkedglycosylation,MaturehumanLYPD-3containstwouPAR/Ly6domainsandaSer/Thr/Pro-rich(STP)regionincludesaproteasesensitivesite.TheinteractionofLYPD-3withLaminin1and5onneighboringcellspromotestheAdhesion,spreADIng,andmigrationoftumorcells.LYPD-3additionallyInteractswithGalectin-3andtheanteriorgradientproteinsAG-2andAG-3.LYPD-3overexpressioninnon-smallcelllungcancerispredictiveofincreasedmortality.
| Source | HEK293 |
| Names | Ly6/PLAURDomain-ContainingProtein3,GPI-AnchoredMetastasis-AssociatedProteinC4.4AHomolog,Matrigel-InducedGeneC4Protein,MIG-C4,LYPD3,C4.4A |
| Accession# | O95274 |
| Formulation | Lyophilizedfroma0.2μMfilteredsolutionof20mMPB,150mMNaCl,pH7.2 |
| Shipping | Theproductisshippedatambienttemperature. |
| Reconstitution | Alwayscentrifugetubesbeforeopening.Donotmixbyvortexorpipetting. Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100μg/ml. Dissolvethelyophilizedproteinin1XPBS. Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles. |
| Storage | Lyophilizedproteinshouldbestoredat<-20°C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7°Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat<-20°Cfor3months. |
| Purity | Greaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE. |
| Endotoxin | Lessthan0.1ng/μg(1IEU/μg). |
| AminoAcidSequence | LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHVDHHHHHH |
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