Methionineaminopeptidase1,METAP,alsonamedMAP1,MetAP1,PeptidaseM1,isamemberoftheM24familyofmetalloproteases.METAPsplayacentralroleforproteinmaturationastheyremovetheinitiatorMetresiduefromnewlysynthesizedproteinsandareessentialforcellgrowth.ThreeMETAPgenes(METAP1,METAP2andMAP1D)havebeenidentifiedinthehumangenome.METAP1andMETAP2havedifferentsubstratespecificityduetothedifferencesinbothsizeandshapeoftheactivesites.METAP1playsanimportantroleinG(2)/Mphaseregulationofthecellcycleandmayserveasapromisingtargetforthediscoveryanddevelopmentofnewanticanceragents.Fumagillin,anaturalcompound,covalentlymodifiesanactiveHisresidueofMETAP2andpreventsthevascularizationandmetasisoftumors.
Source | E.coli |
Names | MethionineAminopeptidase,MAP,PeptidaseM,map |
Accession# | P0AE18 |
Formulation | Suppliedasa0.2μMfilteredsolutionof20mMTris-HCl,100mMNaCl,50%Glycerol,pH8.0 |
Shipping | Theproductisshippedondryice/icepacks. |
Storage | Storeat<-20°C,stablefor6monthsafterreceipt. Pleaseminimizefreeze-thawcycles. |
Purity | Greaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE. |
Endotoxin | Lessthan0.1ng/μg(1IEU/μg). |
AminoAcidSequence | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDELEHHHHHH |
Everest Biotech公司成立于2000年,由英国牛津大学一批生物化学家创建。公司科学家团队具有丰富的抗体纯化及蛋白组学专业知识,雄厚的专业背景赋予了公司能为全球科研人员提供高质量、创新性抗体产品的能力。目前,Everest Biotech可提供3000余种抗体,涉及肿瘤、自身免疫、过敏、心血管疾病、传染病、代谢、神经科学等领域。所有抗体均由Everest Biotech自主研发生产、全部经过肽亲和纯化以保证最佳的特异性和纯度、经过免疫原肽的ELISA和WB实验验证; 由PhD科学家团队提供全方位技术支持服务。Everest Biotech为众多国际知名抗体公司提供OEM服务。